Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway.

The Journal of biological chemistry - 11 Sept 2009

Caohuy Hung, Jozwik Catherine, Pollard Harvey B

Abstract excerpt

The most common mutation in cystic fibrosis (CF) is DeltaF508, which is associated with failure of the mutant cystic fibrosis transmembrane conductance regulator (CFTR) to traffic to the plasma membrane. By a still unknown mechanism, the loss of correctly trafficked DeltaF508-CFTR results in an e...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotinylation
Share to Cystic Fibrosis Transmembrane Conductance Regulator
Share to Dexamethasone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endosomal Sorting Complexes Required for Transport

Share to Epithelial Sodium Channels

Share to Glucocorticoids

Share to Immediate-Early Proteins

Share to Nedd4 Ubiquitin Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 19617352
DOI: 10.1074/jbc.M109.035345
PMCID: PMC2757227

Genes

CFTR
SGK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19617352-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway.PMID 19617352Read ↗

Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants.Semantic proximity Read ↗

Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation.Semantic proximity Read ↗

Role of CFTR's PDZ1-binding domain, NBF1 and Cl(-) conductance in inhibition of epithelial Na(+) channels in Xenopus oocytes.Semantic proximity Read ↗

Localization and function of humanized F508del-CFTR in mouse intestine following activation of serum glucocorticoid kinase 1 and Trikafta.Semantic proximity Read ↗

The short apical membrane half-life of rescued {Delta}F508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of {Delta}F508-CFTR in polarized human airway epithelial cells.Semantic proximity Read ↗

The Relative Binding Affinities of PDZ Partners for CFTR: A Biochemical Basis for Efficient Endocytic RecyclingSemantic proximity Read ↗

Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.Semantic proximity Read ↗

Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motif.Semantic proximity Read ↗

PDZ Domain Interaction Controls the Endocytic Recycling of the Cystic Fibrosis Transmembrane Conductance RegulatorSemantic proximity Read ↗

Ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins CAL and STX6.Semantic proximity Read ↗

ΔF508 CFTR Surface Stability Is Regulated by DAB2 and CHIP-Mediated Ubiquitination in Post-Endocytic CompartmentsSemantic proximity Read ↗

The Delta F508 mutation shortens the biochemical half-life of plasma membrane CFTR in polarized epithelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.