Article
Decreased chloride levels of cerebrospinal fluid in patients with amyotrophic lateral sclerosis.
Journal of the neurological sciences - 15 Oct 2009
Watanabe Shohei, Kimura Takashi, Suenaga Koichi, Wada Sayoko, Tsuda Kenkichi, Kasama Shuhei, Takaoka Toshio, Kajiyama Koji, Takeda Masanaka, Yoshikawa Hiroo
Abstract excerpt
Recent studies have suggested that the elevation of intracellular chloride contributes to excitotoxic cell death in motor neuron and can be related to the pathogenesis of amyotrophic lateral sclerosis (ALS). We investigated whether chloride levels in cerebrospinal fluid (CSF) and serum were lower...
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