Article
Automated multidimensional phenotypic profiling using large public microarray repositories.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2009
Xu Min, Li Wenyuan, James Gareth M, Mehan Michael R, Zhou Xianghong Jasmine
Abstract excerpt
Phenotypes are complex, and difficult to quantify in a high-throughput fashion. The lack of comprehensive phenotype data can prevent or distort genotype-phenotype mapping. Here, we describe "PhenoProfiler," a computational method that enables in silico phenotype profiling. Drawing on the principle that similar gene expression patterns are likely to be associated with similar phenotype patterns, PhenoProfiler...
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