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Article

Chemical Constituents of Propolis from Myanmar and Their Preferential Cytotoxicity against a Human Pancreatic Cancer Cell Line

2 Jul 2009

Abstract excerpt

A methanolic extract of propolis obtained in Myanmar was found to inhibit PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions (NDM), with a PC(50) value of 9.3 microg/mL. Bioactivity-guided fractionation of the extract led to the isolation of two new cycloartane-type triterpenes, (22Z,24E)-3-oxocycloart-22,24-dien-26-oic acid (1) and...

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PMID: 19572611
DOI: 10.1021/np9002433

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