Essentials for starting a pediatric clinical study (3): Dynamic changes in early development of immune system in macaque monkeys--the significance from standpoint of preclinical toxicity test using nonhuman primates.

Abstract excerpt

Macaque monkeys are essential laboratory animals in preclinical safety assessment for human-specific biological products including humanized antibody drug. In most case, investigators are leaving their ages out of consideration, and young individuals aged around 3 years are mainly used because of their small individual differences in biological responses to various stimulations. Since the immune system starts to...

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