Article
Association of HPV16 E6 variants with diagnostic severity in cervical cytology samples of 354 women in a US population.
International journal of cancer - 1 Dec 2009
Zuna Rosemary E, Moore William E, Shanesmith Rebecca P, Dunn S Terence, Wang Sophia S, Schiffman Mark, Blakey Gregory L, Teel Travis
Abstract excerpt
It has been suggested that DNA sequence variants of HPV16 contribute to differences in the behavior of individual cervical lesions. To address this question, we have analyzed the association of HPV16 variants with diagnostic severity in 354 HPV16-positive Oklahoman women. HPV16 variant status was determined by PCR amplification and DNA sequencing of the E6 open reading frame. European sequences were identified in...
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