Article
Mutations in influenza virus replication and transcription: detection of amino acid substitutions in hemagglutinin of an avian influenza virus (H1N1).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2009
Liu Ning, Wang Genyan, Lee Kim Chung, Guan Yi, Chen Honglin, Cai Zongwei
Abstract excerpt
Influenza A viruses are RNA viruses that contain negative-sense, single-stranded, and segmented RNA genome, which depends on virally encoded RNA-dependent RNA polymerase and cellular DNA-dependent RNA polymerase for replication of viral genome and transcription of viral mRNA, respectively. Hemagglutinin (HA), one of the major surface proteins of the influenza virus, is responsible for virus attachment to the...
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