Cytogenetic analysis of a human familial 15p+ marker chromosome.

doi:10.1139/g91-127

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Article

Cytogenetic analysis of a human familial 15p+ marker chromosome.

Genome - 1 Oct 1991

Velázquez M, Visedo G, Ludeña P, de Cabo S F, Sentís C, Fernández-Piqueras J

Abstract excerpt

An extreme variant of a human 15p+ marker chromosome is described in a human family. The short arm of this variant is greatly enriched in ribosomal RNA genes, and there are up to three secondary constrictions potentially active for rRNA transcription. These sites are hypomethylated, whereas the r...

Topics

Blotting, Southern
Cells, Cultured
Chromosome Banding
Chromosomes, Human, Pair 15
DNA Probes
DNA, Ribosomal
Genetic Markers
Genetic Variation
Humans
Plasmids
RNA, Ribosomal, 18S
Restriction Mapping

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