Article
Two clusters of mutations map distinct receptor-binding sites of echovirus 11 for the decay-accelerating factor (CD55) and for canyon-binding receptors.
Virus research - 1 Oct 2009
Rezaikin Alexey V, Novoselov Alexey V, Sergeev Alexander G, Fadeyev Fedor A, Lebedev Sergey V
Abstract excerpt
In this study we present the comparative sequence analysis of the parental haemagglutinating (daf+) and mutant non-haemagglutinating (daf-) clones of echovirus 11 (EV11) isolated from the prototype strain Gregory. The sequence comparison revealed only a single amino acid substitution in the capsid protein VP2 of each mutant clone. These substitutions were located in the area of viral receptor-binding site for...
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