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Article

Family data determine all parameters in Mendelian incomplete penetrance models.

Annals of human genetics - 1 May 1991

Whittemore A S, Keller J B, Ward M J

Abstract excerpt

We show that data on the frequency of occurrence of an hereditary trait in family members can be used to determine all four parameters in a Mendelian genetic model with incomplete penetrance. Thus previous statements in the literature that such data can determine only three combinations of the parameters are incorrect.

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PMID: 1952809
DOI: 10.1111/j.1469-1809.1991.tb00410.x

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