Article
Family data determine all parameters in Mendelian incomplete penetrance models.
Annals of human genetics - 1 May 1991
Whittemore A S, Keller J B, Ward M J
Abstract excerpt
We show that data on the frequency of occurrence of an hereditary trait in family members can be used to determine all four parameters in a Mendelian genetic model with incomplete penetrance. Thus previous statements in the literature that such data can determine only three combinations of the parameters are incorrect.
Topics
- Alleles
- Gene Frequency
- Genetics, Population
- Genotype
- Humans
- Models, Genetic
- Nuclear Family
- Phenotype
- Probability