Article
HLA-A*0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor.
Journal of translational medicine - 12 Jun 2009
Tsukahara Tomohide, Kawaguchi Satoshi, Torigoe Toshihiko, Takahashi Akari, Murase Masaki, Kano Masanobu, Wada Takuro, Kaya Mitsunori, Nagoya Satoshi, Yamashita Toshihiko, Sato Noriyuki
Abstract excerpt
BACKGROUND: To develop peptide-based immunotherapy for osteosarcoma, we previously identified papillomavirus binding factor (PBF) as a CTL-defined osteosarcoma antigen in the context of HLA-B55. However, clinical application of PBF-based immunotherapy requires identification of naturally presented CTL epitopes in osteosarcoma cells in the context of more common HLA molecules such as HLA-A2. METHODS: Ten peptides...
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