Article
Laboratory diagnosis and molecular basis of mild von Willebrand disease type 1.
Acta haematologica - 1 Jan 2009
Michiels Jan Jacques, Berneman Zwi, Gadisseur Alain, van der Planken Marc, Schroyens Wilfried, van Vliet Huub H D M
Abstract excerpt
Mild type 1 von Willebrand disease (VWD) is characterized by low to variable penetrance of bleeding, a high (increased) prevalence of blood group O, von Willebrand factor (VWF) values around and above 30% with normal ratios of VWF:ristocetin cofactor activity (RCo)/VWF:antigen (Ag), VWF:collagen binding (CB)/VWF:Ag and factor VIII (FVIII):coagulant activity (C)/VWF:Ag. Within this group of patients, the...
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