Article
Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study.
BMC cancer - 6 Jun 2009
Nan Hongmei, Qureshi Abrar A, Hunter David J, Han Jiali
Abstract excerpt
BACKGROUND: The human fibroblast growth factor (FGF) and its receptor (FGFR) play an important role in tumorigenesis. Deregulation of the FGFR2 gene has been identified in a number of cancer sites. Overexpression of the FGFR4 protein has been linked to cutaneous melanoma progression. Previous studies reported associations between genetic variants in the FGFR2 and FGFR4 genes and development of various cancers....
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