Article
Polymorphisms in HPV E6/E7 protein interacted genes and risk of cervical cancer in Chinese women: a case-control analysis.
Gynecologic oncology - 1 Aug 2009
Zhou Xiaoyi, Han Suping, Wang Sumin, Chen Xiaojun, Dong Jing, Shi Xiaoyan, Xia Yankai, Wang Xinru, Hu Zhibin, Shen Hongbing
Abstract excerpt
OBJECTIVE: Accumulating studies indicate that HPV E6/E7 oncoproteins interacting genes, TP53, BRCA1 and BARD1, play a critical role in cervical carcinogenesis. We hypothesized that potentially functional polymorphisms in TP53, BRCA1 and BRAD1 may individually and/or jointly contribute to cervical cancer risk. METHODS: We genotyped 4 single nucleotide polymorphisms (SNPs) with amino acid changes, TP53 Pro72Arg...
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