Virulence and Prodigiosin Antibiotic Biosynthesis in<i>Serratia</i>Are Regulated Pleiotropically by the GGDEF/EAL Domain Protein, PigX

Abstract excerpt

Gram-negative bacteria of the genus Serratia are opportunistic human, plant, and insect pathogens. Serratia sp. strain ATCC 39006 secretes pectinases and cellulases and produces the secondary metabolites carbapenem and prodigiosin. Mutation of a gene (pigX) resulted in an extremely pleiotropic phenotype: prodigiosin antibiotic biosynthesis, plant virulence, and pectinase production were all elevated. PigX...

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