Article
Novel mutations in TLR genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection.
BMC genetics - 26 May 2009
Bhide Mangesh R, Mucha Rastislav, Mikula Ivan, Kisova Lucia, Skrabana Rostislav, Novak Michal, Mikula Ivan
Abstract excerpt
BACKGROUND: Toll like receptors (TLR) play the central role in the recognition of pathogen associated molecular patterns (PAMPs). Mutations in the TLR1, TLR2 and TLR4 genes may change the ability to recognize PAMPs and cause altered responsiveness to the bacterial pathogens. RESULTS: The study presents association between TLR gene mutations and increased susceptibility to Mycobacterium avium subsp....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.