Article
Recent progress toward understanding the molecular biology of von Recklinghausen neurofibromatosis.
Annals of neurology - 1 May 1992
Gutmann D H, Collins F S
Abstract excerpt
The gene for von Recklinghausen neurofibromatosis (NF1) was recently identified by positional cloning and found to code for a large, ubiquitously expressed protein. This protein has both structural and functional similarity to a family of proteins with guanosine triphosphatase-activating properties, involved in the regulation of the protooncogene ras. One of the postulated functions of the NF1 gene product may...
Topics
- Forecasting
- Genes
- Genes, Tumor Suppressor
- Humans
- Molecular Biology
- Mutation
- Neurofibromatosis 1
- Neurofibromin 1
- Proteins