Article
Lipoprotein profiles in children with two common cholesteryl ester transfer protein gene mutations, D442G and I14A, during the first year of life.
Clinica chimica acta; international journal of clinical chemistry - 1 Aug 2009
Nagasaka Hironori, Yorifuji Tohru, Momoi Toru, Yorifuji Junko, Hirano Kenichi, Ota Akemi, Takatani Tomozumi, Tsukahara Hirokazu, Takayanagi Masaki, Kobayashi Kunihiko, Chiba Hitoshi, Sato Yukiyasu, Miida Takashi
Abstract excerpt
BACKGROUND: Hyperalphalipoproteinemia is associated with cholesteryl ester transfer protein (CETP) deficiency in adults but has unclear associations in children. METHODS: We measured lipoproteins in 19 heterozygotes (D442G, n=17; I14A, n=2), one D442G/I14A compound heterozygote, 13 non-affected siblings, and 30 healthy controls at birth, 3-4 months, and 12 months. RESULTS: CETP mass was 32-70% lower in...
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