Article
The FHM1 mutation S218L: a severe clinical phenotype? A case report and review of the literature.
Cephalalgia : an international journal of headache - 1 Dec 2009
Debiais S, Hommet C, Bonnaud I, Barthez M A, Rimbaux S, Riant F, Autret A
Abstract excerpt
Familial hemiplegic migraine (FHM) is a rare autosomal dominant subtype of migraine with aura that is characterized by motor weakness during attacks. FHM1 is associated with mutations in the CACNA1A gene located on chromosome 19. We report a severe, prolonged HM attack in a young pregnant patient who had the S218L FHM1. This CACNA1A mutation has been associated with HM, delayed cerebral oedema and coma following...
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