Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

18 May 2009

Abstract excerpt

BACKGROUND: GATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma and respiratory diseases
Share to Cytokine Signaling Pathways and Interactions
Share to Estrogen and related hormone effects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19436703
DOI: 10.1371/journal.pmed.1000076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic DiseasePMID 19436703Read ↗

Regulation of Th2 Cytokine Genes by p38 MAPK-Mediated Phosphorylation of GATA-3Semantic proximity Read ↗

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 GeneSemantic proximity Read ↗

Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3Semantic proximity Read ↗

Expression of GATA family of transcription factors in T-cells, monocytes and bronchial biopsiesSemantic proximity Read ↗

Cutting Edge: Differential Responsiveness of the IL-5 and IL-4 Genes to Transcription Factor GATA-3Semantic proximity Read ↗

Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 CellsSemantic proximity Read ↗

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells.Semantic proximity Read ↗

Gene expression of the GATA-3 transcription factor is increased in atopic asthma.Semantic proximity Read ↗

Role of GATA-3 in IL-5 Gene Transcription by CD4+ T Cells of Asthmatic PatientsSemantic proximity Read ↗

GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factorsSemantic proximity Read ↗

The Function Role of GATA-3 in Th1 and Th2 DifferentiationSemantic proximity Read ↗

A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.