Article
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes.
Nature - 28 May 2009
Glessner Joseph T, Wang Kai, Cai Guiqing, Korvatska Olena, Kim Cecilia E, Wood Shawn, Zhang Haitao, Estes Annette, Brune Camille W, Bradfield Jonathan P, Imielinski Marcin, Frackelton Edward C, Reichert Jennifer, Crawford Emily L, Munson Jeffrey, Sleiman Patrick M A, Chiavacci Rosetta, Annaiah Kiran, Thomas Kelly, Hou Cuiping, Glaberson Wendy, Flory James, Otieno Frederick, Garris Maria, Soorya Latha, Klei Lambertus, Piven Joseph, Meyer Kacie J, Anagnostou Evdokia, Sakurai Takeshi, Game Rachel M, Rudd Danielle S, Zurawiecki Danielle, McDougle Christopher J, Davis Lea K, Miller Judith, Posey David J, Michaels Shana, Kolevzon Alexander, Silverman Jeremy M, Bernier Raphael, Levy Susan E, Schultz Robert T, Dawson Geraldine, Owley Thomas, McMahon William M, Wassink Thomas H, Sweeney John A, Nurnberger John I, Coon Hilary, Sutcliffe James S, Minshew Nancy J, Grant Struan F A, Bucan Maja, Cook Edwin H, Buxbaum Joseph D, Devlin Bernie, Schellenberg Gerard D, Hakonarson Hakon
Abstract excerpt
Autism spectrum disorders (ASDs) are childhood neurodevelopmental disorders with complex genetic origins. Previous studies focusing on candidate genes or genomic regions have identified several copy number variations (CNVs) that are associated with an increased risk of ASDs. Here we present the results from a whole-genome CNV study on a cohort of 859 ASD cases and 1,409 healthy children of European ancestry who...
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