Molecular stratification model for prognosis in cytogenetically normal acute myeloid leukemia.

doi:10.1182/blood-2008-11-187724

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Article

Molecular stratification model for prognosis in cytogenetically normal acute myeloid leukemia.

Blood - 2 Jul 2009

Santamaría Carlos M, Chillón María C, García-Sanz Ramón, Pérez Cristina, Caballero María D, Ramos Fernando, de Coca Alfonso García, Alonso José M, Giraldo Pilar, Bernal Teresa, Queizán José A, Rodriguez Juan N, Fernández-Abellán Pascual, Bárez Abelardo, Peñarrubia María J, Balanzategui Ana, Vidriales María B, Sarasquete María E, Alcoceba Miguel, Díaz-Mediavilla Joaquín, San Miguel Jesús F, Gonzalez Marcos

Abstract excerpt

We have evaluated 9 new molecular markers (ERG, EVI1, MLL-PTD, MN1, PRAME, RHAMM, and WT1 gene-expression levels plus FLT3 and NPM1 mutations) in 121 de novo cytogenetically normal acute myeloblastic leukemias. In the multivariate analysis, high ERG or EVI1 and low PRAME expressions were associated with a shorter relapse-free survival (RFS) and overall survival (OS). A 0 to 3 score was given by assigning a value...

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Identifiers

PMID: 19398719
DOI: 10.1182/blood-2008-11-187724

Genes

ERG
PRAME
FLT3
NPM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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