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Molecular network of the comprehensive multiple sclerosis brain-lesion proteome

23 Apr 2009

Abstract excerpt

BACKGROUND: A recent proteomics study of multiple sclerosis (MS) lesion-specific proteome profiling clearly revealed a pivotal role of coagulation cascade proteins in chronic active demyelination. However, among thousands of proteins examined, nearly all of remaining proteins are yet to be characterized in terms of their implications in MS brain-lesion development. METHODS: By the systems biology approach using...

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PMID: 19389748
DOI: 10.1177/1352458508101943

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