Article
Genotype-phenotype relationship for six common polymorphisms in genes affecting platelet function from 286 healthy subjects and 160 patients with mucocutaneous bleeding of unknown cause.
British journal of haematology - 1 Jun 2009
Martínez Constantino, Antón Ana Isabel, Corral Javier, Quiroga Teresa, Panes Olga, Lozano María Luisa, González-Conejero Rocío, Teruel Raúl, Navarro-Núñez Leyre, Pereira Jaime, Mezzano Diego, Vicente Vicente, Rivera José
Abstract excerpt
Polymorphisms affecting platelet receptors and intracellular proteins have been extensively studied in relation to their potential influence in thrombosis and haemorrhages. However, few reports have addressed their impact on platelet function, with contradictory results. Limitations of these studies include, among others, small number of patients, the platelet functional parameters analyzed and their known...
Topics
- Adolescent
- Adult
- Antigens, Human Platelet
- Blood Platelets
- Case-Control Studies
- Child
- Child, Preschool
- Female
- Genetic Predisposition to Disease