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Article

A new resorufin-based alpha-glucosidase assay for high-throughput screening.

Analytical biochemistry - 1 Jul 2009

Motabar Omid, Shi Zhen-Dan, Goldin Ehud, Liu Ke, Southall Noel, Sidransky Ellen, Austin Christopher P, Griffiths Gary L, Zheng Wei

Abstract excerpt

Mutations in alpha-glucosidase cause accumulation of glycogen in lysosomes, resulting in Pompe disease, a lysosomal storage disorder. Small molecule chaperones that bind to enzyme proteins and correct the misfolding and mistrafficking of mutant proteins have emerged as a new therapeutic approach for the lysosomal storage disorders. In addition, alpha-glucosidase is a therapeutic target for type II diabetes, and...

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Identifiers

PMID: 19371716
DOI: 10.1016/j.ab.2009.04.010
PMCID: PMC2737366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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