Article
Haptoglobin phenotype may alter endothelial progenitor cell cluster formation in cerebral small vessel disease.
Current neurovascular research - 1 Feb 2009
Rouhl R P W, van Oostenbrugge R J, Damoiseaux J G M C, Debrus-Palmans L L, Theunissen R O M F I H, Knottnerus I L H, Staals J E A, Delanghe J R, Tervaert J W Cohen, Lodder J
Abstract excerpt
Cerebral small vessel disease results in silent ischemic lesions (SIL) among which is leukoaraiosis. In this process, endothelial damage is probably involved. Endothelial progenitor cells (EPC), are involved in endothelial repair. By restoring the damaged endothelium, EPC could mitigate SIL and cerebral small vessel disease. Haptoglobin 1-1, one of three phenotypes of haptoglobin, relates to SIL and may therefore...
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