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Article

Different atrophy-hypertrophy transcription pathways in muscles affected by severe and mild spinal muscular atrophy.

BMC medicine - 7 Apr 2009

Millino Caterina, Fanin Marina, Vettori Andrea, Laveder Paolo, Mostacciuolo Maria Luisa, Angelini Corrado, Lanfranchi Gerolamo

Abstract excerpt

BACKGROUND: Spinal muscular atrophy (SMA) is a neurodegenerative disorder associated with mutations of the survival motor neuron gene SMN and is characterized by muscle weakness and atrophy caused by degeneration of spinal motor neurons. SMN has a role in neurons but its deficiency may have a direct effect on muscle tissue. METHODS: We applied microarray and quantitative real-time PCR to study at transcriptional...

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Share to Monomeric GTP-Binding Proteins
Share to Muscular Atrophy, Spinal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to p38 Mitogen-Activated Protein Kinases

Share to Protein Kinases

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Share to Survival of Motor Neuron 1 Protein

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Share to TOR Serine-Threonine Kinases

Source

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Identifiers

PMID: 19351384
DOI: 10.1186/1741-7015-7-14
PMCID: PMC2676312

Genes

MTOR
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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