Article
Modulation of the innate immune response after trauma visualised by a change in functional PMN phenotype.
Injury - 1 Aug 2009
Hietbrink Falco, Koenderman Leo, Althuizen Martje, Leenen Luke P H
Abstract excerpt
BACKGROUND: Acute Respiratory Distress Syndrome (ARDS) is a frequent and severe complication after trauma, caused by an excessive inflammatory response mediated by polymorphonuclear granulocytes (PMNs). It was previously demonstrated that patients with activated PMNs in the lungs have PMNs in the peripheral circulation with a reduced active FcgammaRII up-regulating capacity. We tested the hypothesis that a...
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