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Article

Structure/function analysis of a critical disulfide bond in the active site of L-xylulose reductase.

Cellular and molecular life sciences : CMLS - 1 May 2009

Zhao H-T, Endo S, Ishikura S, Chung R, Hogg P J, Hara A, El-Kabbani O

Abstract excerpt

L-xylulose reductase (XR) is involved in water re-absorption and cellular osmoregulation. The crystal structure of human XR complemented with site-directed mutagenesis (Cys138Ala) indicated that the disulfide bond in the active site between Cys138 and Cys150 is unstable and may affect the reactivity of the enzyme. The effects of reducing agents on the activities of the wild-type and mutant enzymes indicated the...

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Identifiers

PMID: 19337691
DOI: 10.1007/s00018-009-9065-y
PMCID: PMC11131457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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