Article
Safety evaluation of the double mutant 5-enol pyruvylshikimate-3-phosphate synthase (2mEPSPS) from maize that confers tolerance to glyphosate herbicide in transgenic plants.
Regulatory toxicology and pharmacology : RTP - 1 Jul 2009
Herouet-Guicheney Corinne, Rouquié David, Freyssinet Martine, Currier Thomas, Martone Aris, Zhou Junguo, Bates Elizabeth E M, Ferullo Jean-Marc, Hendrickx Koen, Rouan Dominique
Abstract excerpt
Glyphosate tolerance can be conferred by decreasing the herbicide's ability to inhibit the enzyme 5-enol pyruvylshikimate-3-phosphate synthase, which is essential for the biosynthesis of aromatic amino acids in all plants, fungi, and bacteria. Glyphosate tolerance is based upon the expression of the double mutant 5-enol pyruvylshikimate-3-phosphate synthase (2mEPSPS) protein. The 2mEPSPS protein, with a lower...
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