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Article

Biophysical characterization of a new SCN5A mutation S1333Y in a SIDS infant linked to long QT syndrome.

FEBS letters - 4 Mar 2009

Huang Hai, Millat Gilles, Rodriguez-Lafrasse Claire, Rousson Robert, Kugener Béatrice, Chevalier Philippe, Chahine Mohamed

Abstract excerpt

Various entities and genetic etiologies, including inherited long QT syndrome type 3 (LQT3), contribute to sudden infant death syndrome (SIDS). The goal of our research was to biophysically characterize a new SCN5A mutation (S1333Y) in a SIDS infant. S1333Y channels showed the gain of Na(+) channel function characteristic of LQT3, including a persistent inward Na(+) current and an enhanced window current that was...

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Identifiers

PMID: 19302788
DOI: 10.1016/j.febslet.2009.02.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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