Article
Uncovering metabolic pathways relevant to phenotypic traits of microbial genomes.
Genome biology - 1 Jan 2009
Kastenmüller Gabi, Schenk Maria Elisabeth, Gasteiger Johann, Mewes Hans-Werner
Abstract excerpt
Identifying the biochemical basis of microbial phenotypes is a main objective of comparative genomics. Here we present a novel method using multivariate machine learning techniques for comparing automatically derived metabolic reconstructions of sequenced genomes on a large scale. Applying our method to 266 genomes directly led to testable hypotheses such as the link between the potential of microorganisms to...
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