Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Analysis of the Leading Malaria Vaccine Candidate AMA-1 Reveals an Essential Role for the Cytoplasmic Domain in the Invasion Process

6 Mar 2009

Abstract excerpt

A key process in the lifecycle of the malaria parasite Plasmodium falciparum is the fast invasion of human erythrocytes. Entry into the host cell requires the apical membrane antigen 1 (AMA-1), a type I transmembrane protein located in the micronemes of the merozoite. Although AMA-1 is evolving into the leading blood-stage malaria vaccine candidate, its precise role in invasion is still unclear. We investigate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Malaria Research and Control
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19283086
DOI: 10.1371/journal.ppat.1000322

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Analysis of the Leading Malaria Vaccine Candidate AMA-1 Reveals an Essential Role for the Cytoplasmic Domain in the Invasion ProcessPMID 19283086Read ↗

Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasionSemantic proximity Read ↗

Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasionSemantic proximity Read ↗

Functional Characterization of a Redundant Plasmodium TRAP Family Invasin, TRAP-Like Protein, by Aldolase Binding and a Genetic Complementation TestSemantic proximity Read ↗

<i>Babesia divergens</i> and <i>Neospora caninum</i> apical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasionSemantic proximity Read ↗

The Moving Junction Protein RON8 Facilitates Firm Attachment and Host Cell Invasion in Toxoplasma gondiiSemantic proximity Read ↗

<i>Plasmodium</i> GPI-Anchored Micronemal Antigen is essential for parasite transmission through the mosquito hostSemantic proximity Read ↗

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPASemantic proximity Read ↗

Development of Inhibitors of Plasmodium falciparum Apical Membrane Antigen 1 Based on Fragment ScreeningSemantic proximity Read ↗

PfCERLI1 is a conserved rhoptry associated protein essential for Plasmodium falciparum merozoite invasion of erythrocytesSemantic proximity Read ↗

Actomyosin forces and the energetics of red blood cell invasion by the malaria parasite <i>Plasmodium falciparum</i>Semantic proximity Read ↗

Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage developmentSemantic proximity Read ↗

Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparum.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.