Article
Region required for protein expression from the stop-start pentanucleotide in the M gene of influenza B virus.
Journal of virology - 1 Jun 2009
Hatta Masato, Kohlmeier Candice K, Hatta Yasuko, Ozawa Makoto, Kawaoka Yoshihiro
Abstract excerpt
Segment 7 of influenza B virus encodes two proteins, M1 and BM2. BM2 is expressed from a stop-start pentanucleotide, in which the BM2 initiation codon overlaps with the M1 stop codon. Here, we demonstrate that 45 nucleotides of the 3' end of the M1 coding region, but not the 5' end of the BM2 coding region, are sufficient for the efficient expression of the downstream protein. Placing these 45 nucleotides and the...
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