Article
Evaluation of blastomere biopsy using a mouse model indicates the potential high risk of neurodegenerative disorders in the offspring.
Molecular & cellular proteomics : MCP - 1 Jul 2009
Yu Yang, Wu Jindao, Fan Yong, Lv Zhuo, Guo Xuejiang, Zhao Chun, Zhou Rong, Zhang Zhuo, Wang Fuqiang, Xiao Min, Chen Ling, Zhu Hui, Chen Wen, Lin Min, Liu Jiayin, Zhou Zuomin, Wang Liu, Huo Ran, Zhou Qi, Sha Jiahao
Abstract excerpt
Preimplantation genetic diagnosis (PGD), used in clinical practice, is offered to couples that may suffer from a monogenetic disorder, chromosome aneuploidy, or X-linked disease. However, blastomere biopsy, as an indispensable manipulation during the PGD procedure has not been assessed for its long term health implications. Using a mouse model, we investigated the effect of blastomere biopsy of in vitro cultured...
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