Medulloblastoma variants: age-dependent occurrence and relation to Gorlin syndrome--a new clinical perspective.

doi:10.1158/1078-0432.CCR-08-2023

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Article

Medulloblastoma variants: age-dependent occurrence and relation to Gorlin syndrome--a new clinical perspective.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2009

Garrè Maria Luisa, Cama Armando, Bagnasco Francesca, Morana Giovanni, Giangaspero Felice, Brisigotti Massimo, Gambini Claudio, Forni Marco, Rossi Andrea, Haupt Riccardo, Nozza Paolo, Barra Salvina, Piatelli Gianluca, Viglizzo Gianmaria, Capra Valeria, Bruno William, Pastorino Lorenza, Massimino Maura, Tumolo Miriam, Fidani Paola, Dallorso Sandro, Schumacher Riccardo Fabian, Milanaccio Claudia, Pietsch Torsten

Abstract excerpt

PURPOSE: We aimed to test the hypothesis that medulloblastoma (MB) variants show a different age distribution and clinical behavior reflecting their specific biology, and that MB occurring at very young age is associated with cancer predisposition syndromes such as Gorlin syndrome (GS). EXPERIMENTAL DESIGN: We investigated the frequency, age distribution, location, response to treatment, outcome, and association...

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PMID: 19276247
DOI: 10.1158/1078-0432.CCR-08-2023

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