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Article

Galanin receptor subtype 2 suppresses cell proliferation and induces apoptosis in p53 mutant head and neck cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2009

Kanazawa Takeharu, Kommareddi Pavan K, Iwashita Toshihide, Kumar Bhavna, Misawa Kiyoshi, Misawa Yuki, Jang Ilwhan, Nair Thankam S, Iino Yukiko, Carey Thomas E

Abstract excerpt

PURPOSE: Galanin and its three receptors (GALR1-3) are expressed in many normal tissues, but silenced in some tumors. Contradictory roles for galanin and its receptors in various tumors have been reported. To understand their function, investigations of individual galanin receptors are necessary. In head and neck squamous carcinoma cells (HNSCC) with silenced GALR1 and GALR2, we showed that reexpressed GALR1...

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Identifiers

PMID: 19276245
DOI: 10.1158/1078-0432.CCR-08-2443
PMCID: PMC3315370

Genes

GALR2
GALR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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