Article
A systems pathology model for predicting overall survival in patients with refractory, advanced non-small-cell lung cancer treated with gefitinib.
European journal of cancer (Oxford, England : 1990) - 1 May 2009
Donovan Michael J, Kotsianti Angeliki, Bayer-Zubek Valentina, Verbel David, Teverovskiy Mikhail, Cordon-Cardo Carlos, Costa Jose, Greco F Anthony, Hainsworth John D, Parums Dinah V
Abstract excerpt
PURPOSE: To identify clinical and biometric features associated with overall survival of patients with advanced refractory non-small-cell lung cancer (NSCLC) treated with gefitinib. EXPERIMENTAL DESIGN: One hundred and nine diagnostic NSCLC samples were analysed for EGFR mutation status, EGFR immunohistochemistry, histologic morphometry and quantitative immunofluorescence of 15 markers. Support vector regression...
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