Article
Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver.
Physiological genomics - 13 May 2009
Guillén Natalia, Navarro María A, Arnal Carmen, Noone Enda, Arbonés-Mainar José M, Acín Sergio, Surra Joaquín C, Muniesa Pedro, Roche Helen M, Osada Jesús
Abstract excerpt
UNLABELLED: Trans-10, cis-12-conjugated linoleic acid (CLA)-enriched diets promote fatty liver in mice, while cis-9, trans-11-CLA ameliorates this effect, suggesting regulation of multiple genes. To test this hypothesis, apoE-deficient mice were fed a Western-type diet enriched with linoleic acid isomers, and their hepatic gene expression was analyzed with DNA microarrays. To provide an initial screening of...
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