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Article

Tumor suppressor microRNAs are underrepresented in primary effusion lymphoma and Kaposi sarcoma

28 Feb 2009

Abstract excerpt

The presence of tumor-specific microRNAs reflects tissue of origin and tumor stage. We show that the absence of miRNAs likewise can be used to determine tumor origin (miR-155) and proliferation state because tumor suppressor miRNAs (miR-222/221, let-7 family) were significantly down-regulated in primary effusion lymphoma (PEL) and in Kaposi sarcoma (KS), an endothelial cell tumor. PEL and KS are associated with...

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PMID: 19252139
DOI: 10.1182/blood-2008-09-179168

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