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Article

The silkworm mutant lemon (lemon lethal) is a potential insect model for human sepiapterin reductase deficiency.

The Journal of biological chemistry - 24 Apr 2009

Meng Yan, Katsuma Susumu, Daimon Takaaki, Banno Yutaka, Uchino Keiro, Sezutsu Hideki, Tamura Toshiki, Mita Kazuei, Shimada Toru

Abstract excerpt

Tetrahydrobiopterin (BH4) is an essential cofactor for aromatic acid hydroxylases, which control the levels of monoamine neurotransmitters. BH4 deficiency has been associated with many neuropsychological disorders. An inherited defect in BH4 biosynthesis is caused by the deficiency of sepiapterin reductase (SPR), which catalyzes the biosynthesis of BH4 from guanosine triphosphate at the terminal step. The human...

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Identifiers

PMID: 19246455
DOI: 10.1074/jbc.M900485200
PMCID: PMC2670173

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SPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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