Article
Altered expression of key cell cycle regulators in renal cell carcinoma associated with Xp11.2 translocation.
Pathology, research and practice - 1 Jan 2009
Barroca H, Castedo S, Vieira J, Teixeira M, Müller-Höcker J
Abstract excerpt
Renal cell carcinoma (RCC) is a rare tumor in the pediatric population. Recently, a phenotypically and genetically distinct kidney carcinoma, mainly prevalent in children and associated with an Xp11.2 translocation or TFE3 gene fusion, has been described. It has been advanced that in this subtype of RCC, there is an accumulation of cyclin D1, cyclin D3, and p21 ((wafl/cip1)). The aim of the present study was to...
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