Kleemeier Award Lecture 2008--The Canary in the Coal Mine: Telomeres and Human Healthspan

Abstract excerpt

Telomeres, the repeated series of DNA sequences that cap the ends of linear chromosomes, become shorter during cell division and oxidative stress. Shortened telomeres have been documented in a wide variety of pathologies associated with aging and are also predictive of early mortality in the very old. However, telomere shortening--like the canary in the coal mine--is not the cause of the deleterious effects, but...

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