Article
Triosephosphate isomerase activity-deficient mice show haemolytic anaemia in homozygous condition.
Genetics research - 1 Feb 2009
Pretsch Walter
Abstract excerpt
A triosephosphate isomerase (TPI) mutant, Tpi1(a-m6Neu), with approximately 57% residual enzyme activity in blood compared with wild-type was detected among offspring of triethylenemelamine-treated male mice. Homozygous mutants with about 13% residual enzyme activity were recovered in progeny of inter se matings of heterozygotes. The loss of TPI activity was evident both in blood and in other tissue extracts....
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