Article
Genetic analysis of first-trimester miscarriages with a combination of cytogenetic karyotyping, microsatellite genotyping and arrayCGH.
Clinical genetics - 1 Feb 2009
Zhang Y-X, Zhang Y-P, Gu Y, Guan F-J, Li S-L, Xie J-S, Shen Y, Wu B-L, Ju W, Jenkins E C, Brown W T, Zhong N
Abstract excerpt
Miscarriage is the spontaneous loss of an embryo or fetus before the 20th week of pregnancy. Most miscarriages occur before the end of the first trimester (<13 weeks). Although many risk factors relate to this occurrence, genetic factors play the most important role. Chromosomal abnormalities, including both numerical and structural anomalies, underlie the majority of miscarriages. In this study, we employed a...
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