Article
From chromosomal aberrations to mutations in individual genes - the significance of genetic studies of chorions after miscarriage in the search for causes of miscarriages.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians - 1 Dec 2024
Matuszewska Karolina Ewa, Bukowska-Olech Ewelina, Piechota Michał, Staniek-Łacna Katarzyna, Drews Krzysztof, Więckowska Barbara, Koczyk Grzegorz, Popiel Delfina, Dawidziuk Adam, Kochalska Natalia, Milanowska Katarzyna, Białek-Prościńska Agnieszka, Skrzypczak Jana, Hirschfeld Adam Sebastian, Wnuk-Kłosińska Aleksandra, Wiśniewska Marzena, Jamsheer Aleksander, Latos-Bieleńska Anna
Abstract excerpt
OBJECTIVE: To determine the frequency of chromosomal aberrations in chorions after a miscarriage. The second was to examine selected euploid chorions using a next-generation sequencing (NGS) panel designed to assess 43 genes associated with pregnancy loss. MATERIALS AND METHODS: The 1244 chorions were tested by targeted quantitative fluorescent PCR (QF-PCR, 827 chorions) and microarray-based comparative genomic...
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