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Article

Complement 3 deficiency impairs early pregnancy in mice

9 Feb 2009

Abstract excerpt

Human oviductal cells produce complement-3 (C3) and its derivative, iC3b. These molecules are important in immune responses. Our recent study suggested that iC3b also possessed embryotrophic activity and it stimulates the blastulation and hatching rates of in vitro cultured mouse embryos. The objective is to study the impact of C3 deficiency on early pregnancy in vivo using homozygous C3-deficient (C3KO) and...

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PMID: 19205046
DOI: 10.1002/mrd.21013

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