Article
The origin and assembly of a zona pellucida binding protein, IAM38, during spermiogenesis
9 Feb 2009
Abstract excerpt
IAM38 is the most prominent protein of the inner acrosomal membrane extracellular coat (IAMC) of spermatozoa. It is retained by the inner acrosomal membrane after the acrosome reaction and is implicated in secondary sperm-zona binding (Yu et al., Dev Biol2006;290:32-43). Its gene knockout, Zpbp1(-/-), prevents acrosome compaction and leads to acrosome fragmentation and sterility in male mice (Lin et al., Mol Cell...
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