Article
Prolonged remission of disseminated atypical adenomatous hyperplasia under gefitinib.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Feb 2009
Pastorino Ugo, Calabrò Elisa, Tamborini Elena, Marchianò Alfonso, Orsenigo Marta, Fabbri Alessandra, Sozzi Gabriella, Novello Silvia, De Marinis Filippo
Abstract excerpt
Atypical adenomatous hyperplasia (AAH) is a putative precursor of bronchioloalveolar carcinoma (BAC) and adenocarcinoma of the lung, developing from terminal respiratory unit cells. AAH and BAC lesions typically present as ground-glass opacities at spiral chest computed tomography. Epidermal growth factor receptor polysomy/mutations, conferring higher sensitivity to Gefitinib, are frequent in BAC but less common...
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