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PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators

7 Oct 2024

Abstract excerpt

Spermatogenesis is a biological process within the testis that produces haploid spermatozoa for the continuity of species. Sertoli cells are somatic cells in the seminiferous epithelium that orchestrate spermatogenesis. Cyclic reorganization of the Sertoli cell actin cytoskeleton is vital for spermatogenesis, but the underlying mechanism remains largely unclear. Here, we report that the RNA-binding protein PTBP1...

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PMID: 39373517
DOI: 10.1093/nar/gkae862

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